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Overall, the results suggest that RRM2 acts as a pro-oncogenic molecule and may promote the progression of PTC by activating the PI3K/Akt signaling pathway, regulating key proteins of the cell cycle, and inducing the EMT process, which is in high agreement with previous findings in other malignant tumors

Beyond direct antioxidant activity, glutathione plays a central role in phase II liver detoxification the conjugation reactions that convert fat-soluble toxins, heavy metal compounds, and drug metabolites into water-soluble forms for excretion

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Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

Chemical Modifications: Certain peptides (e.g., acetylated, PEGylated) are chemically altered for stability or extended effects