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doi: 10.1155/2020/5245308 181

"FDA approves Myalept to treat rare metabolic disease"

Conclusions and Clinical Importance: Although mean pressure change was generally not statistically significant, tolerance intervals suggest large changes can occur in some animals

F.GharibyanV.AhmedS.JelinekJ.et al (2012)

Reduce systemic adverse reactions and improve skin condition Due to the fact that cream mainly acts locally, the amount of drug entering the systemic blood circulation is relatively small, thus reducing the occurrence of systemic adverse reactions

En este caso, como en los otros casos mencionados, esto nos protege de consecuencias adversas
