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In most cases, mitophagy is triggered upon oxidative stress and serves as a cellular defense mechanism to remove damaged mitochondria that produce high levels of ROS [96]

, However, recent research has cast doubt on this theory by demonstrating that preserving superficial nerve branches during CTR does not lead to a reduction in local postoperative pain

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In addition, we may experience vague and unclear symptoms in the early stages, such as general fatigue, muscle aches, waking up tired

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These effects were magnified in combination therapy protocols , with some studies noting weight reductions of up to 15% when paired with semaglutide
