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It was first characterized by Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, and a 2025 literature and patent review cataloged its effects across gastrointestinal, musculoskeletal, and neural models

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Often, it's deeper systemic issues like hormonal imbalances (androgens are a major culprit), chronic stress (hello, cortisol!), and, increasingly recognized by science, poor gut health and systemic inflammation

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However, Prozac itself does not cause weight gain