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Heavy metals are naturally occurring elements with a large atomic weight and density of at least 5 times greater than that of water (47)

doi: 10.3389/fpsyt.2023.1142608 Received 11 January 2023 Accepted 26 January 2023 Published 09 February 2023 Volume 14 - 2023 Edited by iek Hocaolu, Recep Tayyip Erdoan University, Trkiye Reviewed by Mehmet Hamdi rm, Elaz Eitim Ve Aratrma Hastanesi, Trkiye

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Aside from its role in catecholamine catabolism, COMT converts an antiestrogen compound (2-hydroxyestradiol) to a proestrogen (2-methoxyestradiol) and leads to an estrogen-rich environment