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Description
Subsequently, TMA is transported via the portal circulation to the liver where flavin monooxygenases (FMOs) catalyze the conversion of TMA into TMAO

Evidence points to both central and peripheral proinflammatory mechanisms working alone or together with neurotoxic molecules, such as NH3.59,60 In turn, hyponatremia, sepsis, gastrointestinal bleeding, and kidney failure precipitate the exogenous production of TNF, which exacerbates HE presentation

2007 Nov;48(2):141-4

Some of these genes include LDHB (lactate dehydrogenase B), LIPH, ACSL1 (acyl-CoA synthetase long-chain family member 1), G6PC2 (glucose-6-phosphatase family), and CAMK2B (Ca 2+ /calmodulin-dependent kinase II)

Here is the reality

Joshi 2014
