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N, N-bis (2-hydroxybenzyl) ethylenediamine-N, N-diacetic acid (HBED) binds to Fe 2+ , converting them to Fe 3+ and reducing brain damage caused by Fe 2+

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Exploring the therapeutic potential of natural compounds for Alzheimers disease: Mechanisms of action and pharmacological properties

This allows more efficient conversion to NO where it matters most -- in the blood vessels and muscle tissue

[DOI] [PubMed] [Google Scholar] [51].Tsutsui H, Ide T, Hayashidani S, Suematsu N, Shiomi T, Wen J, Nakamura K, Ichikawa K, Utsumi H, Takeshita A

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Zhu XD, Li SL