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C18 fatty diacid enables weekly dosing

The combination of these adjuvant agents with standard doses of opioids can be used to reduce the risk of complications (e.g., constipation, dizziness, nausea, vomiting, respiratory depression, tolerance, physical dependence) seen in patients using high-dose opioids to alleviate CIPN symptoms

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Surprisingly, we still detected an induction effect of DMF on most of the factors studied despite NRF2 silencing (Fig