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Correspondingly, in K-Ras mutant cells, the oxygen consumption rate and ATP generation are enhanced by glutamine, contributing to tumorigenesis 55

As humas, when we age, cellular repair slows down, hydration levels decrease, oxidative stress increases, and essential nutrient absorption becomes less efficient

10.1055/s-2006-959690 157

doi: 10.1016/S0304-3835(98)00185-2

Additionally, given that GS can accommodate other nitrogen substrates, like hydroxylamine (common in vitro assay for activity 2 ) and methylamine (physiologically provided by host microbiome 30 ), it is possible that various GS homologues may harbor different catalytic functions beyond or in addition to glutamine synthesis

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