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Reproductive health research reveals significant applications in studying age-related endocrine dysfunction, with laboratory studies showing that FOXO4-DRI improves the testicular microenvironment and alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged male mice

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This metabolic improvement occurs through AMPK pathway activation and increased NAD+-dependent SIRT1 activity, both of which enhance insulin receptor signaling and glucose metabolism