glutathione nucleophile Model of Glo2 catalysis. The position of the nucleophile-generating Glutathione catalysis and the reaction

& Walter, H

59,60 GO nanogels loaded with etoposide not only enhance drug delivery but also upregulate pro-apoptotic genes and downregulate anti-apoptotic genes in breast cancer cells, thereby inhibiting the proliferation of MCF-7 tumor cells

They screened six differentially expressed ferroptosis-related genes (IL6, ANGPTL7, CDKN1A, AKR1C3, NOX4, and VLDLR) and constructed a random forest model based on these genes, which demonstrated strong diagnostic performance in the validation dataset, highlighting the close relationship between ferroptosis and immunity in atherosclerosis pathogenesis (61)

The underlying mechanisms responsible for the lack of response among patients are yet to be fully understood

6 and 7)

21 , 22 There are also many studies on the oxidative stress mechanism of CRS