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Front Cell Dev Biol 13:1611055
According to nutritional conditions, the levels of amino acids may vary, being cysteine, glutamate, and glycine the most important for glutathione synthesis
Under pro-inflammatory conditions, as evidenced by interventions with LPS or IFN-, microglia are insensitive to ferroptosis, yet susceptible to iron overload ( in vitro data showed that genetic depletion of iNOS renders Raw264.7 cells and EOC 20 cells vulnerable to ferroptosis, whereas NO donors (SNAP, DPTA-NONOate) empower the ferroptotic resistance of M2 microglia ( The sophisticated interplay between neuroinflammation, instigated by microglia in response to inflammatory stimuli, and ferroptosis in microglia has been documented
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10.1186/s12940-016-0159-3 72 ObaedN
Interestingly, the Arabidopsis lines showed a genotype-specific adaptation to 14 days of excess light
