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Selenium plays an important role in regulating thyroid hormone metabolism and may improve the function of the thyroid gland in subclinical hypothyroidism by promoting better conversion of T4 to the active form T3 [23]

However, GLRX has five cysteines that are potentially vulnerable to oxidative modification, which is associated with GLRX aggregation and loss of activity

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The former can be detected using inductively coupled plasma-MS or calcein AM quenching, as well as other specific iron probes (Hirayama and Nagasawa, 2017