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Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trmbach D, Mao G, Qu F, Bayir H, Fllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Figure 10A shows the results obtained upon monitoring cellular morphological changes in A375 cells treated for 48 h with IC 50 doses of 1P and 1A using Hoechst 33258 fluorescent staining analysis

doi: 10.1177/1933719113518984

10.21037/atm-22-4603 196 WangX.WeiL.LiQ.LaiY

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A major result of this is the depletion of GSH, and disruption of the GPX4 antioxidant pathway, leading to massive lipid peroxidation and cell death [83]
