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Without it, cells struggle to maintain redox balance, leading to metabolic inefficiencies

In diet-induced obese (DIO) mouse models, NNMT inhibition led to approximately 35% reduction in white adipose tissue mass compared to controls

This muscle-sparing effect distinguishes it from many other fat loss approaches including some GLP-1 medications and severe caloric restriction

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Effects of NNMT inhibitors on lipogenesis and intracellular levels of metabolites, including NNMT reaction product 1-methylnicotianamide (1-MNA) were evaluated in cultured adipocytes

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