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This mitochondrial failure is the direct biochemical driver of the profound, debilitating fatigue and post-exertional malaise (PEM) that patients experience after even minor physical or cognitive exertion

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Alternatively, some GPx-1-deficient cells may be overwhelmed by oxidants because they lack other partially compensatory antioxidant mechanisms, resulting in heightened sensitivity to ROS and a lack of adequate pro-survival signaling

Sathyanarayanan V, Oki Y, Issa AK, Ahmed MA, Noorani M, Fanale MA, Hagemeister FB, Neelapu SS, Nastoupil LJ, Fowler N, Turturro F, Davis ER, Rodriguez A, Wang M , Feng L, Young KH, McDonnell TJ, Pinnix CC, Fayad LE, Westin JR

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