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According to ICH [50]ICH Q2 (R1), Validation of analytical procedures: text and methodology, in Proceedings of the International Conference on Harmonization, Geneva, Switzerland, 2005

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PSPH was found to be overexpressed in CRC tissues, and its expression levels were positively associated with the depth of invasion and the occurrence of distant metastasis and functioned as an independent indicator of clinical prognosis, which were corroborated by the bioinformatics analysis [84]

Authors:Blahos J, Fischer T, Brabet I, Stauffer D, Rovelli G, Bockaert J, Pin JP, Journal:J Biol Chem PubMed ID:11027680 'Specific domains of the G-protein alpha subunit have been shown to control coupling to heptahelical receptors

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