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In the STZ animal model of AD, a chronic treatment with the CB 1 receptor agonist ACEA induced a reduction of nitric oxide (NO) accompanied by an improvement of the short- and long-term working memory measured by novel object recognition test (van der Stelt et al., 2006)

Regulatory managers should make sure that the quality systems used by suppliers can handle both sending in the Drug Master File and being inspected by regulatory authorities

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