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In addition to these metabolic disruptions, aberrant epigenetic modifications (5), altered nuclear factor activity, and mitochondrial dysfunction induced by hyperglycemia (6), all contribute to the excessive generation of ROS in DR

doi: 10.3389/fendo.2023.1324429 25 AounTDanielova GueorguievaDWuKY

Field observations on the long-term liming experiments at Rothamsted and Woburn

Editor information Editors and Affiliations Rights and permissions Copyright information 2015 Springer-Verlag Berlin Heidelberg About this entry Cite this entry Pickart, L., Vasquez-Soltero, J.M., Margolina, A

Reduced glutathione (GSH) is the biologically active form used by the body
For instance, in cells for which maintaining redox homeostasis is more important than nucleic acid synthesis, the PPP is tailored to accelerate the oxidative branch and to direct the nonoxidative branch towards re-synthesizing F6P from pentose phosphate, which is then converted back to G6P to replenish the oxidative branch (Fig
