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ROS must pass through the mitochondrial membrane to enter the cytoplasm, and the destruction of mitochondrial membrane integrity and loss of membrane potential lead to the release of ROS into the cytoplasm [54]

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Oxidative/nitrosative stress is associated with widespread protein and lipid (per)oxidation, which reduces antioxidative capacity and shifts the intracellular redox status toward an oxidized state (Reiniers et al