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Gastric Acid Secretion: Enterochromaffin-like cells (ECL) cells that line the stomach produce histamine

doi: 10.1002/mus.20840

How to read preclinical evidence without over-reading it Preclinical does not mean worthless it means early

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Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue