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The oxidative stress caused by a decrease in GSH levels can then impact microglia function and potentially lead to a more pro-inflammatory M1 phenotype that has reduced -amyloid clearance capabilities (Vilhardt et al., 2017)

adults have low B12 levels, especially vegetarians, vegans, and older adults

Conditions involving intestinal inflammation, barrier dysfunction, or ulceration may respond to the peptide reparative effects, particularly when administered orally for direct tissue contact

Studies using APP/PS1 micea well-established model of Alzheimer's pathologydemonstrate that Dihexa administration restored spatial learning and cognitive functions to near-wildtype levels as measured by Morris water maze performance