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For metabolism of NR, NRK1 is expressed in most tissues but is absent in the spleen and white adipose tissue, while NRK2 is only present in skeletal muscle, heart, and white adipose tissue (WAT) 40

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It plays a critical role in detoxifying heavy metals and pollutants, synthesizing DNA, activating enzymes, and regulating various cellular processes

Nevertheless, the normalization of blood vessels by targeting VEGF anti-tumor angiogenesis therapy is short-lived