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Side effects are rare but may include mild discomfort at the injection site, nausea, or digestive upset

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PMID 2306116

They catalyze the reduction of disulfide bonds formed during S-glutathionylation, returning the modified proteins to their reduced, functional state

A study where healthy individuals received a -HB infusion to achieve a concentration of approximately 5.5 mmol/L demonstrated a 14% reduction in brain glucose utilization and a significant 30% increase in cerebral blood flow, with unchanged oxygen consumption [77]

The H 2 O 2 generated can then be decomposed into nontoxic H 2 O and O 2 by means of other antioxidant enzymes such as catalase (CAT)