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12 Diagnosis Presumptive diagnosis of feline HL can be made on the basis of clinical history, physical examination, clinicopathologic features, ultrasound examination, and liver aspirates.1, 13, 14, 15 Ultrasound examination of the liver often reveals hepatic parenchyma that is hyperechoic to that of falciform fat, but a thorough ultrasound evaluation of the gallbladder, pancreas, intestines, kidneys, bladder, and other abdominal structures is essential to rule out other primary disorders, such as acute pancreatic necrosis, which may be the basis of the anorectic event precipitating an episode of HL

The function of mitochondria also plays a vital role in cell health, intercellular communication, regulated cell death, and cell growth

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489 Both MT overexpression and direct MT administration can reduce DCM by suppressing peroxynitrite-derived nitrosative damage and ROS production in diabetic hearts

doi: 10.1038/cdd.2017.170 43 ZhengJAsakawaTChenYZhengZChenBLinMet al

2019, 144, e58882