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The Sikiric group has proposed several overlapping mechanisms: Nitric Oxide System Multiple rodent studies from the Zagreb group show BPC-157 influences endothelial nitric oxide synthase (eNOS) activity

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Mechanistic research has investigated GHK-Cu as a regulator of gene expression in dermal fibroblast research models, with broad effects observed across genes involved in extracellular matrix remodeling, copper homeostasis, antioxidant defense, and tissue signaling (Pickart & Margolina, 2018)

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