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10.3390/biomedicines9111506 87 StrinicD.Belosic HalleZ.LueticK.NedicA.PetrovicI.SucicM.et al (2017)

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The blood glucose-lowering effect of the plant was first described in 1656 by Thomas Culpeper, but at that time it was difficult to identify the ingredient that was responsible for these effects

For example: Some gut problems get better with diet changes that eliminate known trigger foods