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This amino acid serves as a primary building block for protein

Injected intratumorally, this compound decreased tumor mass and increased the survival of GL261 glioma-bearing mice, underscoring the involvement of EAAT1 in Glu trafficking in gliomas, and further confirming that this transporter supports glioma cell proliferation [38]

Studies in human embryonic kidney 293 (HEK 293) cells overexpressing hOAT3 showed that there was an enhanced uptake of MPAG (Uwai et al., 2007), morinidazole glucuronides (Zhong et al., 2014), daidzein-7-O-glucuronide, genistein-7-O-glucuronide, glycitein-7-O-glucuronide and quercetin-3-O-glucuronide (Wong et al., 2011), which suggested that OAT3 contributes to the renal tubular secretion of these glucuronide conjugates

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