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Further, a secondary analysis of a trial in women at high risk for or with existing cardiovascular disease reported that high-dose supplemental B-vitamins (1 mg/day of vitamin B 12 , 50 mg/day of vitamin B6, and 2.5 mg/day of folic acid) for 7.3 years had no effect on risk of non-vertebral fractures (122)

Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

On the one hand, the application of these new technologies provides ideas for the study of the pharmacological mechanism of TMMM, linking the chemical metabolites of drugs with potential targets, and predicting the pathway of drug action

10.1038/s41598-021-90934-9 83 R Core Team (2024)

Serum B12 alone can sometimes be misleading MMA levels provide a more functional assessment of whether your body is actually utilizing the B12 available to it

doi: 10.1093/cvr/cvx108 [DOI] [PMC free article] [PubMed] [Google Scholar] 146