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[3] Mitochondrial electron transport chains [edit] Most eukaryotic cells have mitochondria, which produce ATP from reactions of oxygen with products of the citric acid cycle, fatty acid metabolism, and amino acid metabolism

FA cells detect the lack of ironsulfur cluster biosynthesis as a deficit in iron availability, leading to the upregulation of iron import proteins such as TfR and the downregulation of the only known iron exporter, Fpn, to increase intracellular iron levels