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This overexposure pattern depletes intracellular antioxidants, disrupts redox balance and leads to adverse effects, including cell apoptosis, proliferation inhibition, and functional impairment

doi: 10.1146/annurev.immunol.14.1.649

J Clin Endocrinol Metabol 86:15041510 Ben-Amitai D, Laron Z (2009) Insulin-like growth factor-1 (IGF-1) deficiency prevents the appearance of pre-acne and acne (Abstract PO2-186) 8th Joint Meeting of the LWPES/ESPE, New York, 912 Sep 2009

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doi: 10.1016/j.bbi.2009.02.013

In the case of co-cultured SH-SY5Y cells, the opposite results were obtained: (+)-limonene was more efficient without FAC pretreatment, and SO EO was more potent in the presence of iron in decreasing caspase-3 activity compared to 6-OHDA-treated SH-SY5Y cells (Fig