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The use of scaffold-based 3D models to study ECs behavior and molecular mechanisms is also more frequent in cancer research, namely to investigate angiogenesis associated with tumorigenesis, and still very scarce for ECD investigation in the context of CVDs [245, 247]

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Many recent studies found that the long-term use of metformin could be a cause for increasing the prevalence of peripheral neuropathy among T2DM patients[13,31,42,43]

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