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When pitolisant blocks the H3 receptor, this disinhibits, or turns on, the release of histamine (bottom right)

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doi: 10.2337/db12-1115 63 TeschGH

The prevalent causes of vitamin B 12 deficiency are (1) an autoimmune condition known as pernicious anemia, and (2) a disorder called food-bound vitamin B 12 malabsorption

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Ro 25-6981 and CP-101,606 also cross-discriminate with phencyclidine in drug discrimination paradigms in rats [158, 159] and primates [159] and CP-101,606 is self-administered by primates experienced in self-administration of phencyclidine [159], indicating that some GluN2B NAMs share discriminative stimulus properties with the channel blocker phencyclidine