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External and internal factors that induce oxidative stress can also activate sEH via oxidative intra-disulfide formation

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AJ: Conceptualization, Data curation, Formal analysis, Software, Writing original draft

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Timing and frequency considerations Half-life and clearance: Determines dosing frequency

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Tendons and ligaments require mechanical loading in the correct dose and direction to reorganize collagen and improve tensile capacity

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BS1801, an analog of ebselen, is currently undergoing clinical trials for the treatment of liver fibrosis and PF [176]

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