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Synapse 1999;31(4): 285-289

4 Transaminase Upregulation and Targeting Amino Acid Synthesis for Cancer Therapy Another means of inhibiting glutaminolysis is to target alanine transaminase through L-cycloserine or aspartate transaminase through the inhibitor amino oxyacetate, which could almost completely halt the growth of breast cancer in xenograft mice [117, 118]

This is now a common theme underlying insulin resistance in other insulin-sensitive tissues such as skeletal muscle

Lastly, glycine, which is utilized by the small intestine to synthesize the antioxidant glutathione, along with methionine and cysteine, plays a protective role in intestinal immune and anti-oxidative responses

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By intercepting these potentially harmful electrophiles, GSH is important in the defense against foreign substances