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The 2 individual patient-reported components (stool frequency and rectal bleeding) are part of the Mayo score and were not powered for statistical significance VISIBLE 1 TRIAL EXPLORATORY END POINTS: PATIENT-REPORTED OUTCOMES Partial Mayo Score and symptom subscores by study visit 15 * The ENTYVIO IV arm is a reference arm and not powered for statistical significance

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J Biomed Mater Res B Appl Biomater 85(2):326333

Asp can form a cyclic imide intermediate that either regenerates the original amino acid or converts to iso-aspartate, an isomer with different properties

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Conclusions The updated model provided a general characterisation of semaglutide pharmacokinetics following oral, subcutaneous and intravenous administration in healthy subjects and subjects with type 2 diabetes