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In both studies independently, PROZAC produced a statistically significantly greater mean change on the Childhood Depression Rating Scale-Revised (CDRS-R) total score from baseline to endpoint than did placebo

Unfortunately, theres a ton of confusion about this

Several patents are available for drug delivery via the nasal route to either directly target the CNS, or by systemic transport of the drugs by the nasal route to target the CNS

All group means are presented in Table 3

doi:10.4162/nrp.2010.4.3.229

Valproic acid has a bunch of different potential uses, so Id like to dig into the patient history and see what the indication is