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The authors also wish to acknowledge Ms

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In addition, APIJNS exhibits efficient CAT-like activity, which can catalyze the production of O 2 from overexpressed H 2 O 2 in TME, which not only alleviates the hypoxia within the tumor lesion, but also converts it into 1 O 2 to activate the photosensitizer ICG and enhance the effect of PDT for synergistic antitumor effects