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10.1038/383710a0 [DOI] [PubMed] [Google Scholar] Dumont M., Kipiani K., Yu F., Wille E., Katz M., Calingasan N

Therefore, as circulating LCACs have been independently associated with CVDs and type 2 diabetes, the intersection of these two associations with the pathogenesis and progression of diabetic cardiomyopathies is currently unknown

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The number of included studies was limited, most being small-sample and short-term clinical trials, and the lack of large-scale, robust RCTs restricts the strength of the conclusions

In addition, they do not have US FDA approval, nor do they have the European/UK CE mark for medical devices