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NAD + is also a precursor to cyclic ADP-ribose (cADPR), a secondary signaling molecule generated by enzymes such as cluster of differentiation 38 (CD38) 7 , and it can be hydrolyzed by sirtuins, which deacetylate histones and regulate gene expression 7

In contrast, treatment with ACore alone and in combination with A42 resulted in a rescue of PSD volume (mean value of 0.27 m 3 ) similar to that seen with untreated controls or treatment with ACore alone (mean value of 0.26 m 3

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