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This is why a gradual dose titration schedule is standard practice
J Biol Chem 292:1731217323 Laurence A, Pesu M, Silvennoinen O, OShea J (2012) Suppl 2: JAK kinases in health and disease: an update
A 2003 study by Khavinson et al
Brett, J
& Sambrook, J
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