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Mercado, N., Ito, K

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Thus, genome editing therapies can be developed to silence bad genes [65,66,67]

Farina AR, Cappabianca L, DeSantis G, Di Ianni N, Ruggeri P, Ragone M, Merolle S, Tonissen KF, Gulino A, Mackay AR (2011) Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells

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The alkylation of 4-hydroxythalidomide with tert-butyl bromoacetate to obtain a carboxylic acid derivative in order to facilitate the binding to the amine-terminal linker, for example, was carried out by Lis group in order to synthesize different cereblon-based PROTACs promoting the degradation of the 20S proteasome subunit 5