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Lind J, Nordlund P

Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]

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CoQ10 shares the same biochemical pathway as cholesterol, so if you use a cholesterol killer youll knock out that pathway, said Sinatra

The specific mechanisms of action lie in the formation of hydrogen bonds between CGA and lipase, hydrophobic interactions between tryptophan (Trp) near the benzene ring and acyl binding bag, and weak interactions, such as van der Waals forces with surrounding amino acid residues, which together competitively inhibit the binding sites of endogenous lipase and lipoxygenase (LOX) (109)