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Mechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide

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Gut microbiota is involved in the synthesis of biological metabolites in the digestive tract [53]

Advanced molecular studies reveal that FOXO4-DRI promotes p53 nuclear exclusion and subsequent mitochondrial targeting, where p53 interacts with BCL-2 family proteins to promote mitochondrial outer membrane permeabilization and cytochrome c release