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A spot urine sample (approximately 50 ml) was collected 4 h following anti-TB drug dosing and frozen at -80C until analysis

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In the SELECT trial, patients did not enroll for the specific purpose of weight loss and received standard of care covering management of CV risk factors, including medical treatment and healthy lifestyle counseling, but without a specific focus on weight loss

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However, additional clinical trials are necessary to prove its effectiveness

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It has been reported that Caspase-1 activity and mature IL-1 levels are significantly increased in steatohepatitis models ( Classical NLRP3 inflammasome activation requires active Caspase-1

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Additional comparison of these findings to the phosphoproteomics datasets identified an increase in phosphorylation of SMARCC2 at Thr 548 following combination drug treatment (Figure 5d)

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Updated October 25, 2021

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