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Experience of sapropterin dihydrochloride monotherapy is mainly limited to mild forms of PTPSD with minimal or even absent clinical symptoms, and normal levels of dopamine and serotonin metabolites in CSF [44]

Furthermore, animal studies suggest that identifying biomarkers of autoantibody production could aid in early diagnosis and risk stratification for patients at risk of developing DHF [119,122]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Gojkovic S., Krezic I., Vrdoljak B., Malekinusic D., Barisic I., Petrovic A., Pavlov K.H., Kolovrat M., Duzel A., Knezevic M., et al

A few practical takeaways from this list: DOD is the biggest funder but has the most opaque process

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