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Melatonins potential to strengthen the BBB appears to involve the upregulation of tight junction proteins, including claudin-5, zonula occludens-1, and occluding [191], which help shield the brain from harmful substances in the bloodstream [192]

Kim HJ, Jang BK, Park JH, Choi JW, Park SJ, Byeon SR, Pae AN, Lee YS, Cheong E, Park KD (2020a) A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

scrutinized the involvement of neutrophils in tumor necrosis within a mouse model of glioblastoma (GBM) steered by the PDZ-binding motif [124]

Wu J, Minikes AM, Gao M, et al