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However, its common for blood tests to reveal inaccurate information regarding B12 levels since a high percentage is stored in the liver and not always revealed through testing (for example, taking large amounts of folic acid has been found to mask vitamin B12 deficiency in some patients)

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We reasoned that mouse models of 22q11.2DS might have metabolic disturbances similar to those reported in patients, in which case the in vivo genetic and pharmacological manipulation of the model should provide insights into the contribution of the metabolic phenotypes to the disease pathogenesis and/or disease mechanisms