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It is a topic of continued scientific and clinical study

Withdrawal criteria of this study were those subjects who experienced adverse drug reactions during the study, subjects who could not comply with the study protocol or those who wished to voluntarily withdraw from the study, and any subject who required other medication during the study period
doi: 10.1016/j.jhevol.2013.04.003

JOR Spine 2 , e1050 (2019)

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Stacking them targets both sides of the energy balance equation simultaneously, which is why the combination generates interest
