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A primary concern is the limited toxicity data on commonly used excipients, particularly regarding their long-term effects on the nasal mucosa

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These extremely rare side effects include: Reactive thrombocytosis during the first week of use in megaloblastic anaemia Hypersensitivity reactions including: rash, itching, exanthema, antibodies to HYDR0XOCOBALAMIN-transcobalamin II Anaphylaxis Hypokalaemia Headache, paraesthesia, tremor Irregular heartbeat (arrhythmias secondary to hypokalaemia) Nausea Vomiting Diarrhoea Fever, chills, hot flushes, dizziness, malaise, pain and / or swelling at the injection site Acne Abnormal colouration of the urine (chromaturia) B12 injections work quickly

Reconstitution behavior and solubility profiling across solvent systems

It is often prescribed for individuals with pernicious anemia or other conditions that impair B absorption (for example, after gastric surgery or in certain digestive disorders)
